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This analysis aimed to determine the rate of, and factors associated with visual success following diabetic vitrectomy performed for Indigenous and non-Indigenous Australians, and investigate factors predisposing to early progression to diabetic retinopathy (DR) requiring vitrectomy. Visual outcomes following diabetic vitrectomy have not previously been studied in an Australian population.

Kaidonis, Georgia Hassall, Mark M Phillips, Russell Raymond, Grant Saha, Niladri Wong, George Hc Gilhotra, Jagjit S Liu, Ebony Burdon, Kathryn P Henderson, Tim Newland, Henry Lake, Stewart R Craig, Jamie E Visual outcomes following vitrectomy for diabetic retinopathy amongst Indigenous and non-Indigenous Australians in South Australia and the Northern Territory. After vitrectomy for DME, visual acuity and CFT improved significantly in both groups, but only patients treated with kallidinogenase continued to have significant improvement throughout the study period. In the study group, the visual acuity and CFT significantly improved from 3 to 12 months and from 6 to 12 months, whereas these parameters did not continue to improve in the control group after 6 months (for visual acuity) or 3 months (for CFT). At 12 months, the mean CFT decreased significantly in both groups, with no significant difference in the rate of change between the two groups. The degree of improvement did not differ significantly between the groups. Visual acuity improved significantly at 12 months in both groups compared with before surgery. During follow-up, 11 patients dropped out (six in the study group and five in the control group), leaving 28 eyes in 28 patients for analysis (13 in the study group and 15 in the control group). The main outcome measurements included logMAR visual acuity and central foveal thickness (CFT) before surgery and at 3, 6, 9, and 12 months after vitrectomy.

This study was designed as a prospective, randomized, multicenter study comparing 19 eyes of 19 patients who received 150 units of kallidinogenase administered a day for 52 weeks from the day after vitrectomy (study group) with 20 eyes of 20 patients who received no kallidinogenase (control group). To evaluate the effectiveness of the combination of vitrectomy with kallidinogenase for diabetic macular edema (DME). Yoshizumi, Yuki Ohara, Zaigen Tabuchi, Hitoshi Sumino, Hitomi Maeda, Yukiko Mochizuki, Hideki Yamane, Ken Kiuchi, Yoshiaki Effects of kallidinogenase in patients undergoing vitrectomy for diabetic macular edema.